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Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study not conducted in compliance with GLP and test standard not specified in the report, however data is included for the OECD SIDS Dossier.
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
other: SIDS Dossier Data
Title:
Unnamed
Year:
1973
Report date:
1997

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Method not specified; however given the age of the study, a standard acute method is most appropriate.
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Benzenamine, 2-ethyl-N-(2-ethylphenyl)-, (tripropenyl) derivs.
EC Number:
271-800-7
EC Name:
Benzenamine, 2-ethyl-N-(2-ethylphenyl)-, (tripropenyl) derivs.
Cas Number:
68608-77-5
IUPAC Name:
3,5-diallyl-N-(3-allyl-2-ethylphenyl)-2-ethylaniline
Test material form:
liquid: viscous
Details on test material:
CAS number: 68608-77-5
CAS Descriptor: Benzenamine, 2-ethyl-N-(2-ethylphenyl)-, (tripropenyl) derivatives
EINECS-Number: 271-800-7
Molecular Weight: 225-479

Test animals

Species:
rabbit
Strain:
other: New Zealand White
Sex:
not specified
Details on test animals or test system and environmental conditions:
Not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Details on dermal exposure:
The test material was applied to a shaved area on the backs of four rabbits and then covered with an impervious plastic sheeting.
Duration of exposure:
4 hours
Doses:
Not specified
No. of animals per sex per dose:
Four animals
Control animals:
no
Details on study design:
After 4 hours the test material was removed, and the sites were examined for local reactions. Animals were observed for toxic signs; body weights were recorded at the beginning of the study and at the end of the 14-day observation period.
Statistics:
Not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 3 000 mg/kg bw
Based on:
not specified
Mortality:
No mortality was observed at any of the doses.
Clinical signs:
other: Skin reactions were limited to mild erythema, desquamation, and edema. Only barely perceptible to slight erythema and desquamation were present at day 14.
Gross pathology:
Not specified
Other findings:
Not specified

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 > 3000 mg/kg bw (LD50 not specified within the study report, but assumed to be LD50 based on the effects noted).
Executive summary:

Study not conducted in compliance with GLP and test standard not specified within the study report, however data included for the OECD SIDS dossier. Result: > 3000 mg/kg bw ( LD50 not specified within the study report, but assumed to be LD50 based on the effects noted). Read across to supporting substance, CAS No. 68608 -77 -5, by structural analogue.