N,N-diethylaniline

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from secondary source

Data source

Reference

Reference Type:

secondary source

Title:

Screening-level hazard characterization: Monocyclic Aromatic Amines Category

Author:

US Environmental Protection Agency

Year:

2009

Bibliographic source:

U.S. Environmental Protection Agency September, 2009 Hazard Characterization Document

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

Acute dermal toxicity of test chemical in rabbits

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

N,N-diethylaniline

EC Number:

202-088-8

EC Name:

N,N-diethylaniline

Cas Number:

91-66-7

Molecular formula:

C10H15N

IUPAC Name:

N,N-diethylaniline

Test material form:

liquid

Details on test material:

- Name of test material (as cited in study report): N,N-Diethylaniline
- Molecular formula: C10-H15-N
- Molecular weight: 149.236 g/mol
- Smiles notation: c1(N(CC)CC)ccccc1
- InChl: 1S/C10H15N/c1-3-11(4-2)10-8-6-5-7-9-10/h5-9H,3-4H2,1-2H3
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

not specified

Administration / exposure

Type of coverage:

not specified

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

not specified

Duration of exposure:

Exposure period unspecified

Doses:

468 and 935 mg/kg-bw

No. of animals per sex per dose:

4/dose

Control animals:

not specified

Details on study design:

not specified

Statistics:

not specified

Results and discussion

Effect levels

Effect levels 1

Sex:

not specified

Dose descriptor:

LD0

Effect level:

468 mg/kg bw

Based on:

test mat.

Remarks on result:

other: No mortality

Effect levels 2

Sex:

not specified

Dose descriptor:

LD100

Effect level:

935 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 100 % mortality

Mortality:

No mortalities occurred at 468 mg/kg-bw and all animals died at 935 mg/kg-bw.

Clinical signs:

other: not specified

Gross pathology:

not specified

Other findings:

not specified

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category III

Conclusions:

The acute dermal LD50 value was considered to be <935 mg/kg bw when rabbits were treated with test chemical via dermal route.

Executive summary:

Acute dermal toxicity study test chemicalwas conducted on rabbits at the dose concentration of 468 and 935 mg/kg bw. The test chemical was administered via dermal route. All animals were maintained under close observation for recording toxic signs and time of death for 14 days.No mortalities were observed at 468 mg/kg-bw and all animals died at 935 mg/kg-bw. Thus the Lethal dose, 50 percent kill value (LD50) of test chemical for dermal toxicity in rabbit in between 468 and 935 mg/kg bw. This value suggests that test chemical is toxic by the dermal route and will be classified in category 3 for acute dermal toxicity. (LD0 is used for classification instead of LD50)