Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-791-8 | CAS number: 10361-44-1
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- A written assessment of toxicokinetic behaviour is considered appropriate for the substance. The substance displays only minor toxicological effects in any of the studies proposed, and is deemed to be be not harmful for health effects. As such, it is deemed inappropriate in terms of animal welfare to conduct a toxicokinetic assessment when no harmful effects are predicted based on known toxicology. A written assessment has therefore been prepared to address this endpoint.
Data source
Materials and methods
- Principles of method if other than guideline:
- A written assessment based on the toxicological profile of the substance.
Test material
- Reference substance name:
- Bismuth trinitrate
- EC Number:
- 233-791-8
- EC Name:
- Bismuth trinitrate
- Cas Number:
- 10361-44-1
- Molecular formula:
- Bi(NO3)3
- IUPAC Name:
- bismuth(3+) trinitrate
- Details on test material:
- Name: Bismuth trinitrate
Constituent 1
Test animals
- Species:
- other: not applicable
- Details on test animals or test system and environmental conditions:
- Not applicable
Administration / exposure
- Route of administration:
- other: not applicable
- Details on exposure:
- Not applicable
- Duration and frequency of treatment / exposure:
- Not applicable
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Not applicable
- No. of animals per sex per dose / concentration:
- Not applicable
- Positive control reference chemical:
- Not applicable
- Details on study design:
- Not applicable
- Details on dosing and sampling:
- Not applicable
Results and discussion
- Preliminary studies:
- Not applicable
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Not applicable
- Details on distribution in tissues:
- Not applicable
- Details on excretion:
- Not applicable
Metabolite characterisation studies
- Details on metabolites:
- Not applicable
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: low bioaccumulation potential based on review of study results
- Executive summary:
A toxicokinetics assessment was conducted for bismuth trinitrate using available data including data from the published literature. Based on the results of this assessment, the substance is considered to have low bioaccumulation potential.
Value used for CSA:
Bioaccumulation potential: low bioaccumulation potential
Absorption rate - oral (%): 1
Absorption rate - dermal (%): 0.1 (dry exposure)
Absorption rate - inhalation (%): 1
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
