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EC number: 700-330-1 | CAS number: 433733-92-7
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05 May - 15 October 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- -1.97
- Temp.:
- 20 °C
- pH:
- 7
- Details on results:
- No test substance was detected in the pretreated samples from the blank mixture.
The recoveries of the test substance in the test samples were between 102% and 107%. The analysed concentration of the stock solution was 4.82 g/l. Based on this the nominal quantity of the test substance in the test samples was 9.6 mg. - Conclusions:
- The shake flask method was chosen for the determination of the partition coefficient of the test substance.
The Pow value of the test substance is: 1.06 x 10^-2
The log Pow value of the test substance is: -1.97
Reference
Pow of the test substance
Ratio |
Analysed concentration |
Pow |
log Pow |
pH |
|
n-octanol |
water |
||||
1:1 |
1.57 ^ 10-2 |
1.66 |
9.45 ^ 10-3 |
-2.02 |
7.0 |
1.74 ^ 10-2 |
1.70 |
1.02 ^ 10-2 |
-1.99 |
7.0 |
|
1:2 |
9.64 ^ 10-3 |
1.24 |
7.78 ^ 10-3 |
-2.11 |
7.0 |
1.92 ^ 10-2 |
1.22 |
1.57 ^ 10-2 |
-1.80 |
7.0 |
|
2:1 |
2.60 ^ 10-2 |
2.42 |
1.07 ^ 10-2 |
-1.97 |
7.2 |
2.41 ^ 10-2 |
2.43 |
9.92 ^ 10-3 |
-2.00 |
7.3 |
|
Mean |
1.06 ^ 10-2 |
-1.97 |
|||
Standard deviation |
2.68 ^ 10-3 |
||||
Recoveries
Ratio |
Analysed quantity |
Recovery |
||
n-octanol |
water |
total |
||
1:1 |
0.0943 |
9.97 |
10.1 |
104 |
0.104 |
10.2 |
10.3 |
107 |
|
1:2 |
0.0386 |
9.91 |
10.0 |
103 |
0.0769 |
9.79 |
9.87 |
102 |
|
2:1 |
0.208 |
9.68 |
9.88 |
103 |
0.193 |
9.72 |
9.91 |
103 |
|
Description of key information
The shake flask method was chosen for the determination of the partition coefficient of the test substance.
The Pow value of the test substance is: 1.06 x 10^-2
The log Pow value of the test substance is: -1.97
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -1.97
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
