Registration Dossier
Registration Dossier
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EC number: 700-144-0 | CAS number: 13115-71-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
After uptake (orally, intravenously) of Glycyl-L-glutamine the concentration in blood is assumed to reach steady state levels. For risk assessment purposes oral absorption of Glycyl-L-glutamine is set at 100%.
Glycyl-L-glutamine is of low volatility due to a very low vapour pressure (0.00000084 Pa). From this and from the particle size it is not expected that Glycyl-L-glutamine reaches the nasopharyncheal region or subsequently the tracheobronchial or pulmonary region in significant amounts.
However, being a very hydrophilic substance with a molecular mass of only 203.2 g/mol, any Glycyl-L-glutamine reaching the lungs might be absorbed through aqueous pores (ECHA, 2008). For risk assessment purposes, although it is unlikely that Glycyl-L-glutamine will be available to a high extent after inhalation via the lungs due to the low vapour pressure and high MMAD, the inhalation absorption of Glycyl-L-glutamine is set at 100%.
Glycyl-L-glutamine with high water solubility (129.9 g/L at 20°C) and the log P value below 0 (-3.18) may be too hydrophilic to cross the lipid rich environment of the stratum corneum. Therefore, 10% dermal absorption of Glycyl-L-glutamine is proposed for risk assessment purposes.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 100
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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