Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 APR 2021 - 03 JUN 2021
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- adopted 13 April 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
- Version / remarks:
- August 1996
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Commission Regulation (EU) 2016/266 A.24. Partition Coefficient (n-Octanol/Water), High Performance Liquid Chromatography (HPLC) Method
- Version / remarks:
- EC Publication No. O.J. L54/1, 01 March 2016
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 7.37
- Temp.:
- 25 °C
- pH:
- 6.373
- Conclusions:
- The extrapolated Pow is 23349315 and the extrapolated log Pow is 7.37.
- Executive summary:
The partition coefficient test was performed according to the OECD guideline 117, EU method A.24 and OPPTS 830.7570 under GLP compliance. In the course of this study the partition coefficient (Pow) of the test item was determined using high performance liquid chromatography. Retention time measured for the test item (5.655 min) is higher than last eluting standard (4,4’-DDT; 4.681 min). This result shows that log Pow of the test item is beyond the calibrated range. The extrapolated Pow is 23349315 and the extrapolated log Pow is 7.37.
Reference
Results
The three calibration series and three test item series were measured alternately. The partition coefficient Pow was determined based on a calibration curve using six reference substances. The capacity factors (k) were calculated from the dead time and retention times of the reference substances. The log k data of the reference substances were plotted against their log Pow values.
Mean of the measured and calculated data of the test item
| Retention time (min) | log K (extrapolated, mean) | log Pow (extrapolated, mean) | Pow (extrapolatd, mean) | Repeatability log unit |
| 5.650 | 0.433 | 7.37 | 23349315 | 0.015 |
| 5.649 | ||||
| 5.651 | ||||
| 5.650 | ||||
| 5.662 | ||||
| 5.668 | ||||
| Mean : 5.655 |
Description of key information
The partition coefficient test was performed according to the OECD guideline 117, EU method A.24 and OPPTS 830.7570 under GLP compliance. In the course of this study the partition coefficient (Pow) of the test item was determined using high performance liquid chromatography. Retention time measured for the test item (5.655 min) is higher than last eluting standard (4,4’-DDT; 4.681 min). This result shows that log Pow of the test item is beyond the calibrated range. The extrapolated Pow is 23349315 and the extrapolated log Pow is 7.37.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 7.37
Additional information
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