Registration Dossier
Registration Dossier
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EC number: 641-487-5 | CAS number: 40150-92-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- No single animal data provided; Relevant details on materials and methods (e.g. test substance concentration) not provided
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-[4-(2-methylpropyl)phenyl]ethan-1-ol
- Cas Number:
- 40150-92-3
- Molecular formula:
- C12 H18 O
- IUPAC Name:
- 1-[4-(2-methylpropyl)phenyl]ethan-1-ol
- Details on test material:
- No further data provided
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- not specified
- Controls:
- yes
- Amount / concentration applied:
- 0.1 (unit not given) of liquid test material (not specified, if applied undiluted)
- Duration of treatment / exposure:
- 7 days
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- Ocular lesions were scored by Draize method approximately 1 hour, 1, 2, 3, 4 and 7 days after treatment.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Remarks:
- maximum mean Draize score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 44.7
- Max. score:
- 110
- Reversibility:
- fully reversible within: 7 days
- Irritant / corrosive response data:
- - Conjunctivae: Slight to moderate irritation in 3/3 animals (1h and 24 hours),
cleared with time (minimal at day 4; no irritation at day 7).
- Cornea (dullling of the cornea) in 3/3 animals (1h); progress to scattered opacity over
most of the cornea for 4 days.
- Iris: Slight to moderate iritis for 3-4 days in 2/3 animals.
Treated eyes were free of effects 7 days after treatment.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
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