2-methylbenzene-1,4-diyl bis{4-[3-(acryloyloxy)propoxy]benzoate}

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

19 APR 2000 - 15 JUN 2000

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

guideline 92/69/EEC

Deviations:

no

GLP compliance:

yes

Type of method:

column elution method

Water solubility:

< 0.005 mg/L

Conc. based on:

test mat. (total fraction)

Temp.:

20 °C

pH:

6.89

VISUAL ESTIMATION

Even in a total volume of 1000 mL undissolved particles could be observed. Thus the water solubility of the test substance is less than 10 mg/L.

COLUMN-ELUTION METHOD

The coating check was successful

According to the guideline, the data of the fractions 1 to 5 were not taken into account for the following evaluation. The following values for the water solubility were calculated from the fractions 6 to 15 for both columns. Fraction 16 and all following fractions were discarded without determination of any parameter.

Result run 1 : Evaluation of the fractions 6 to 15. The water solubility was found to be less than 0.0054 mg/L for all fractions. Average water solubility: < 0.0054 mg/L.

Result run 2: Evaluation of the fractions 6 to 15. The water solubility was found to be less than 0.0052 mg/L for all fractions. Average water solubility: < 0.0052 mg/L.

The water solubility (ws) of the test substance at a temperature of 20 °C was determined as follows (average over both runs):

ws < 0.0053 mg/L

SD = 0.0002 mg/L

RSD = 3%

Conclusions:

The water solubility (ws) was found to be:
ws < 0.0053 mg/l
SD = 0.0002 mg/l
RSD = 3%

Executive summary:

The water solubility (ws) of the test substance has been determined according to the "column-elution" method following guideline 92/69/EEC, appendix A.6, according to GLP at a temperature of 20 °C.

It was found to be:

ws < 0.0053 mg/L

SD = 0.0002 mg/L

RSD = 3%

Description of key information

The water solubility (ws) of the test substance has been determined according to the "column-elution" method following guideline 92/69/EEC, appendix A.6, according to GLP, at a temperature of 20 °C.

It was found to be:

ws < 0.0053 mg/L

SD = 0.0002 mg/L

RSD = 3%

Key value for chemical safety assessment

Water solubility:

0.005 mg/L

at the temperature of:

20 °C

Additional information

Determined value for water solubility is below the above mentioned value, because HPLC peak area is below a calculated value based on the minimum visible peak are. This does not affect the chemical safety assessment because the water solubility is in any case very low.