Imidazolium compounds, 1-[2-(2-carboxyethoxy)ethyl]-1(or 3)-(2-carboxyethyl)-4,5-dihydro-2-norcoco alkyl

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Remarks:

measured as Critical Micellization Concentration

Type of information:

experimental study

Adequacy of study:

key study

Study period:

July 06, 2018 - May 3rd, 2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Qualifier:

no guideline available

Principles of method if other than guideline:

The Critical Micellization Concentration is defined as the concentration of surfactants above which micelles form and all additional surfactants added to the system go to micelles. This concentration is determined by measuring the surface tension of solutions at different concentrations. The surface tension consists in a measurement of the maximum vertical force necessary to separate a ring from its contact with the surface of the liquid being examined. These measurements are performed in a thermo-regulated cup at the requested temperature, which is 20.0°C ± 1.0°C. The surface tension is defined as the free surface enthalpy per unit of surface and is expressed in mN/m.

GLP compliance:

yes (incl. QA statement)

Type of method:

other: surface tension measurement

Key result

Water solubility:

17 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

>= 3.9 - <= 4.1

Conclusions:

The Critical Micellization Concentration of the test item was determined to be 17.0 mg/L at 20.0 °C ± 1.0 °C.

Executive summary:

The Critical Micellization Concentration (CMC) of the test item was determined in a GLP-compliant study by measuring the surface tension of test item solutions at different test item concentrations. The CMC of the test item was 17.0 mg/L at 20.0 °C ± 1.0 °C.

Reference 2

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

July 18, 2018 - March 14, 2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

>= 205 g/L

Conc. based on:

test mat.

Remarks:

determined from the quantitative analysis of C12 amphopropionic acid

Temp.:

20 °C

pH:

>= 3.9 - <= 4.2

Key result

Water solubility:

>= 202 g/L

Conc. based on:

test mat.

Remarks:

determined from the quantitative analysis of acrylic acid

Temp.:

20 °C

pH:

>= 3.9 - <= 4.2

PRELIMINARY TEST

Through the serial volume addition of water to the test item, the following table shows the solubility in water of the test item at 20.0 °C ± 2.0 °C.

Weight of the test item (g)	Volume of water (mL)	Solubility* (g/L)
0.11179	0.1	No	/
	0.5	No	/
	1	No	/
	2	No	/
	10	Yes	10-50

*Solubility:

No: Undissolved material was visually observable in the test solution.

Yes: No undissolved material was visually observable in the test solution.

Conclusions:

The water solubility of the test item at 20.0°C ± 2.0°C was determined to be ≥ 202-205 g/L from the quantitative analysis in the test solutions of its main constituents, C12 amphopropionic acid and acrylic acid.

Executive summary:

The water solubility of the test item was investigated in a GLP-compliant study performed in accordance with EU Method A.6 (Water Solubility) and OECD Guideline 105 (Water Solubility). The water solubility of the test item at 20.0°C ± 2.0°C was determined to be ≥ 202-205 g/L from the quantitative analysis in the test solutions of its main constituents, C12 amphopropionic acid and acrylic acid.

Description of key information

The water solubility of the test item was investigated in a GLP-compliant study (Ricau, 2019) performed in accordance with EU Method A.6 (Water Solubility) and OECD Guideline 105 (Water Solubility). The water solubility of the test item at 20.0°C ± 2.0°C was determined to be ≥ 202-205 g/L from the quantitative analysis in the test solutions of its main constituents, C12 amphopropionic acid and acrylic acid.

In addition, the Critical Micellization Concentration (CMC) of the test item was determined in a GLP-compliant study (Demangel, 2019) by measuring the surface tension of solutions at different concentrations. The CMC of the test item was 17.0 mg/L at 20.0 °C ± 1.0 °C.

Key value for chemical safety assessment

Water solubility:

202 g/L

at the temperature of:

20 °C

Additional information

The water solubility of the test item was investigated in a GLP-compliant study (Ricau, 2019) performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and was selected as key study for the endpoint.

In addition, the Critical Micellization Concentration (CMC) of the test item was investigated in a GLP-compliant study (Demangel, 2019) performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and was also selected as key study for the endpoint.