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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- Danish QSAR battery approach for allergic contact dermatitis is applied as well as analysis of CLP data of all constituents according to C&L regulation based on actual analytical information of the constituents in intermediate substance.
- Type of information:
- (Q)SAR
- Remarks:
- Actual analytical information of the constituents in intermediate substance used as input to Danish QSAR battery approach for allergic contact dermatitis is applied as well as analysis of CLP data of all constituents according to C&L database.
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- The valid Danish QSAR database, Battery model that integrates results from all systems of CASE Ultra, Lead Scope,SciQSAR, is applied for allergic contact dermatitis in guinea pig and human using actual GC-MS (and headspace) data as well as C>4 hydrocarbons from EPI Suite. Due to complex combination of hydrocarbons as UVCB intermediate substance, the input data for Danish QSAR software was actual substance constituents using GC-MS (and headspace) as well as EPI suite available data for C>4 hydrocarbons to provide a comprehensive assessment that cover complete range of known and probable hydrocarbons. In addition, all constituents hazard properties for skin sensitization were analyzed using ECHA C&L database.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 019
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Two methods applied together for assessment:
First, valid Danish QSAR database, Battery model that integrates results from all systems of CASE Ultra, Lead Scope,SciQSAR, is applied for allergic contact dermatitis in guinea pig and human using actual GC-MS (and headspace) data of the intermediate substance. In addition, C>4 hydrocarbons representative information is also added to broaden the analysis from EPI Suite. Due to complex combination of hydrocarbons as UVCB intermediate substance, the input data for Danish QSAR software was actual substance constituents using GC-MS (and headspace) as well as EPI suite available data for C>4 hydrocarbons to provide a comprehensive assessment that cover complete range of known and probable hydrocarbons.
Second, all constituents hazard properties for skin sensitization were checked using ECHA C&L database to find which constituent has skin sensitization potential. In order to be more conservative, some constituents that are not assigned with exact CAS number in the GCMS results but reported as isomers of a known constituent were also analyzed. For those isomers, all possible known structures were considered for hazard properties according to ECHA C&L database. The purpose was to evaluate if total concentration of skin sensitizers may add more than 1% according to CLP regulation for classification. - GLP compliance:
- no
- Type of study:
- other: Danish QSAR battery approach for allergic contact dermatitis is applied as well as analysis of CLP data of all constituents according to C&L regulation based on actual analytical information of the constituents in intermediate substance.
Test material
- Reference substance name:
- Hydrocarbons from mixed waste plastics, thermo-mechanical depolymerization condensate
- Molecular formula:
- C5-C29
- IUPAC Name:
- Hydrocarbons from mixed waste plastics, thermo-mechanical depolymerization condensate
- Test material form:
- liquid
- Details on test material:
- Hydrocarbons from mixed waste plastics, thermo-mechanical depolymerization condensate. It is a complex combination of hydrocarbons as described in section one.
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
Results and discussion
In vitro / in chemico
Results
- Key result
- Parameter:
- other: Danish QSAR battery approach for allergic contact dermatitis is applied as well as analysis of CLP data of all constituents according to C&L regulation based on actual analytical information of the constituents in intermediate substance.
- Remarks on result:
- other: Danish QSAR battery approach for allergic contact dermatitis is applied as well as analysis of CLP data of all constituents according to C&L regulation based on actual analytical information of the constituents in intermediate substance.
- Remarks:
- Both assessment approaches from DTU QSAR results and evaluation of all constituents against C&L inventory data revealed No skin sensitization potential.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Both assessment approaches from DTU QSAR results and evaluation of all constituents against C&L inventory data revealed as no skin sensitization potential and therefore, GHS criteria not met.
- Executive summary:
Two methods applied together for assessment:
First, valid Danish QSAR database, Battery model that integrates results from all systems of CASE Ultra, Lead Scope,SciQSAR, is applied for allergic contact dermatitis in guinea pig and human using actual GC-MS (and headspace) data of the intermediate substance. In addition, C>4 hydrocarbons representative information is also added to broaden the analysis from EPI Suite. Due to complex combination of hydrocarbons as UVCB intermediate substance, the input data for Danish QSAR software was actual substance constituents using GC-MS (and headspace) as well as EPI suite available data for C>4 hydrocarbons to provide a comprehensive assessment that cover complete range of known and probable hydrocarbons.
Second, all constituents hazard properties for skin sensitization were checked using ECHA C&L database to find which constituent has skin sensitization potential. In order to be more conservative, some constituents that are not assigned with exact CAS number in the GCMS results but reported as isomers of a known constituent were also analyzed. For those isomers, all possible known structures were considered for hazard properties according to ECHA C&L database. The purpose was to evaluate if total concentration of skin sensitizers may add more than 1% according to CLP regulation for classification. However, evaluation resulted in no skin sensitizer in the constituents.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.