Registration Dossier
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EC number: 614-657-1 | CAS number: 68609-08-5
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2007-11-5 to 2008-02-26
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study was regarded as reliable because it was conducted in compliance with GLP regulation and guidelines.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995-07-27
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- Commission Directive 92/69/EEC, Annex V
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- 03/1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- ca. 13.8 mg/L
- Temp.:
- 20 °C
- pH:
- ca. 8
- Details on results:
- The water solubility of the test item was determined to be 13.8 ± 2.3 mg/L (95 % confidence interval) at 20 °C ± 1 °C using the shake-flask method for the performance of the main test.
- Conclusions:
- The water solubility of the test item was determined to be 13.8 ± 2.3 mg/L (95 % confidence interval) at 20 °C ± 1 °C using the shake-flask method for the performance of the main test.
- Executive summary:
A preliminary test for solubility was carried out as a range finding test for the decision which method has to be used for the performance of the main test. The water solubility of the test item was estimated to be 10.2 mg/L, therefore, the shake-flask method according to OECD TG 105 was used for the main test. In the main test the water solubility of the test item was determined to be 13.8 ± 2.3 mg/L (95 % confidence interval) at 20 °C ± 1 °C.
Reference
A preliminary test for solubility was carried out as a range finding test for the decision which method has to be used for the performance of the main test. The solubility of the test item was higher than 10 mg/L, therefore, the shake-flask method was used for the main test.
The calibration curve was constructed using six solutions and applying linear regression.
The calibration samples were analysed by reversed phase HPLC method with three parallel injections from each. The concentrations were calculated with the help of the calibrations equations.
Description of key information
The water solubility of the test item was determined to be 13.8 ± 2.3 mg/L (95 % confidence interval) at 20 °C ± 1 °C using the shake-flask method for the performance of the main test.
Key value for chemical safety assessment
- Water solubility:
- 13.8 mg/L
- at the temperature of:
- 20 °C
Additional information
A preliminary test for solubility was carried out as a range finding test for the decision which method has to be used for the performance of the main test. The water solubility of the test item was estimated to be 10.2 mg/L, therefore, the shake-flask method according to OECD TG 105 was used for the main test. In the main test the water solubility of the test item was determined to be 13.8 ± 2.3 mg/L (95 % confidence interval) at 20 °C ± 1 °C.
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