Registration Dossier
Registration Dossier
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EC number: 302-853-7 | CAS number: 94134-83-5
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- The justification for type of information is provided in attachment.
Bioaccumulation experimental study is not a data requirement in accordance with Annexes VII and VIII. BCF prediction is provided in order to support PBT/vPvB assessment under Annex XIII. Although the prediction shows some restrictions in terms of reliability, it's deemed to be adequate to suitably exclude B/vB classification. - Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.
- Key result
- Type:
- BCF
- Value:
- 9 L/kg
- Remarks on result:
- other: Parameters such as pH value, temperature, etc. are not specified by the QSAR model.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Overall, the predicted BCF (i.e. 9 L/kg) allows to exclude the B/vB classification under Annex XIII of REACH Regulation.
Reference
The prediction shows some restrictions in terms of reliability. However, the QSAR model has a tool which allows to quantify the uncertainty in the prediction in order to carry out PBT/vPvB assessment under Annex XIII.
The predicted logBCF is equal to 0.95 (that is 9 L/kg).
For the threshold logBCF = 3.3 (i.e. threshold for B classification), the current compound can be associated (due to its Applicability Domain index value) to a conservative interval of 0.7 log units. On this basis, the compound can be safely classified as not bioaccumulative.
For the threshold logBCF = 3.7 (i.e. threshold for vB classification), the current compound can be associated (due to its Applicability Domain index value) to a conservative interval of 0.5 log units. On this basis, the compound can be safely classified as not very bioaccumulative.
Description of key information
The substance has a predicted BCF of 9 L/kg.
Key value for chemical safety assessment
- BCF (aquatic species):
- 9 L/kg ww
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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