Registration Dossier
Registration Dossier
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EC number: 206-746-5 | CAS number: 372-18-9
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- no
- Other quality assurance:
- ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
- Type of method:
- flask method
Test material
- Reference substance name:
- 1,3-difluorobenzene
- EC Number:
- 206-746-5
- EC Name:
- 1,3-difluorobenzene
- Cas Number:
- 372-18-9
- Molecular formula:
- C6H4F2
- IUPAC Name:
- 1,3-difluorobenzene
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 0.762 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 6.2
Any other information on results incl. tables
No. |
Solution |
Mass taken (g) |
pH at 20℃ |
Peak area |
Average value of peak areas |
Factor ( f) |
Average Value off |
Mass concentration (g/mL, 20℃) |
1 |
STD1 |
0.02000 |
/ |
48.546 |
/ |
1.2145E+05 |
/ |
/ |
2 |
A |
/
|
6.2 |
93.227 |
93.352 |
/ |
1.2022E+05 |
7.765E-04 |
|
|
|
|
|
|
|
3 |
93.476 |
4 |
STD2 |
0.02480 |
/ |
58.982 |
/ |
1.1900E+05 |
/ |
/ |
5 |
B |
/
|
6.2 |
93.314 |
93.113 |
/ |
1.2107E+05 |
7.691E-04 |
|
|
|
|
|
|
|
6 |
92.912 |
7 |
STD1 |
0.02000 |
/ |
49.226 |
/ |
1.2315E+05 |
/ |
/ |
8 |
C |
/
|
6.2 |
89.703 |
89.664 |
/ |
1.2121E+05 |
7.398E-04 |
|
|
|
|
|
|
|
9 |
89.625 |
10 |
STD2 |
0.02480 |
/ |
59.111 |
/ |
1.1926E+05 |
/ |
/ |
The relative difference of the concentrations measured in the three flasks respectively:
A-B，1.0 %； A-C，4.8 %； B-C，3.9 %
The concentrations measured in the three flasks do not differ by more than 15% each other, the test is satisfactory and the average value of all results can be calculated as the water solubility.
The last result of water solubility is the mean of the concentrations measured in the three flasks: [(7.765+7.691+7.398)×10-4/3] g/mL = 0.762 g/L, and pH = 6.2。
Applicant's summary and conclusion
- Conclusions:
- 0.762 g/L (20°C pH 6.2)
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