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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
02 May 2018 to 25 May 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
1.9 g/L
Conc. based on:
test mat.
Temp.:
20 °C
Remarks on result:
other: +- 0.1 g/L

Table 1: Summary of Water Solubility Results

 Days at 30 °C Sample   Concentration (g/L)  pH
 1  1 A  1.675  6.7
   1 B  1.812  6.7
 2  2 A  2.009  6.9
   2 B  1.898  6.9
 3  3 A  1.900  6.9
   3 B  1.970  6.8
Mean 1.9 g/L 
Standard Deviation 0.1 g/L 
 RSD

 2.8 %

Table 2: Water solubility results

 Sample  Peak Area  Concentration; CA (mg/L)  Dilution Factor  Concentraion, CB (mg/L)
 22.90 mg/L std  26.274  -  -  -
 Sample 1 A  38.471  33.50  50  1.675
 Sample 1 B  41.628  36.25  50  1.812
 Sample 2 A  46.148  40.18  50  2.009
 Sample 2 B  43.606  37.97  50  1.898
 22.90 mg/L std  26.325  -  -  -
 Sample 3 A  44.553  38.01  50  1.900
 Sample 3 B  46.184  39.40  50  1.970
 22.90 mg/L std  27.359  -  -  -

Table 3: Standard Calibration

 Standard Calibration (mg/L)

 Peak Area

 45.79

 54.467

 36.63

 44.637

 27.48

 30.637

 18.32

 20.427

 9.158

 9.288

 Linear Regression

 y = 1.25x - 2.483

 r

 0.9987
Conclusions:
The water solubility of the test item was determined to be 1.9 +/- 0.1 g/L at 20 °C.
Executive summary:

The water solubility of the test item was determined in a study following OECD 105 and EC Method A6 guidelines, using the flask method. The water solubility of the test item was determined to be 1.9 +/- 0.1 g/L at 20 °C.

The study is a GLP compliant, guideline experimental study and is fully acceptable for assessment of this endpoint.

Description of key information

The water solubility of the test item was determined to be 1.9 +/- 0.1 g/L at 20 °C.

Key value for chemical safety assessment

Water solubility:
1.9 g/L
at the temperature of:
20 °C

Additional information

The water solubility of the test item was determined in a study following OECD 105 and EC Method A.6 guidelines, using the flask method (Dunning 2018). The water solubility of the test item was determined to be 1.9 +/- 0.1 g/L at 20 °C.

 

The study is a GLP compliant, guideline experimental study and is fully acceptable for assessment of this endpoint.