Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 939-579-8 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Additional information
To assess the stability of Chimexane HB, one hydrolysis study was performed, according to OECD-Guideline No.111 (2004) with GLP statement, with test item concentration of 1 mg/L in buffer solutions at pH 4, 7 and 9 at a test temperature of 50°C (preliminary test).
Samples were taken at test start (0h), 2, 4h and test end (120h) and analysed via UPLC-MS/MS on a reversed phase column using an external standard. Buffer solutions were analysed at test start and test end with no interference with the test item. The analytical method for determination of the test item CHIMEXANE HB 1667 (lyophilised) was validated and tested with satisfactory results in regard to linearity, repeatability of injections, accuracy , precision and specificity.
Degradation was calculated as the percentage loss of the test item over the time. In the preliminary test, the test item was found to be stable at pH 4, 7 and 9, respectively. No further testing was deemed necessary as less than 10% of the applied test item were hydrolysed after 120h (5 days) at each of the three pH values. Reaction rate constants and half lives could not be calculated due to the fact that the test item undergoes no significant hydrolysis. With reference to the guideline a half life of > 1 year could be assumed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
