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Diss Factsheets

Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
other information
Study period:
2012
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract

Data source

Reference
Reference Type:
publication
Title:
Triphenyl phosphite, a new allergen in polyvinylchloride gloves
Author:
Katri Suuronen, Maria Pesonen, Maj-Len Henriks-Eckerman and Kristiina Aalto-Korte
Year:
2012
Bibliographic source:
Contact Dermatitis, 68, 42–49

Materials and methods

Type of sensitisation studied:
skin
Study type:
case report

Test material

Constituent 1
Chemical structure
Reference substance name:
Triphenyl phosphite
EC Number:
202-908-4
EC Name:
Triphenyl phosphite
Cas Number:
101-02-0
Molecular formula:
C18H15O3P
IUPAC Name:
triphenyl phosphite

Method

Type of population:
other: patients
Subjects:
- Number of subjects: 5
- Patients with suspected PVC glove contact allergy
Route of administration:
dermal
Details on study design:
The patients were patch tested with the newly obtained test substances, plastics and glues series, and isocyanates and isocyanate prepolymers. Nine PVC glove samples were analysed for the test item and its derivatives.

Results and discussion

Results of examinations:
Two patients reacted to a technical PVC antioxidant and one of its components (the test substance). Contact allergy to the test item was very strong in 1 patient, and was the main cause of her hand dermatitis, whereas the other patient also had other contact allergies explaining her symptoms. Three patients reacted to their PVC gloves, but the specific allergen was not identified. Six PVC glove samples contained the test item at concentrations of 0.004–0.099%. The test item transforms into the phosphate during storage.

Applicant's summary and conclusion

Conclusions:
The test item represents a new allergen in PVC gloves. It was detected in several PVC gloves in fairly high concentrations.
Executive summary:

Background.


Contact allergy to polyvinylchloride (PVC) gloves has been reported relatively seldom. In spring 2011, 5 of our patients had patch test reactions to PVC gloves. We obtained a collection of PVC raw materials from industrial producers and suppliers of chemical compounds to be patch tested on patientswith suspected PVC glove contact allergy.


Objectives.


To report the first results of these new test substances.


Methods.


The patients were patch tested with the newly obtained test substances, plastics and glues series, and isocyanates and isocyanate prepolymers. We analysed nine PVC glove samples for the test item and its derivatives.


Results.


Two patients reacted to a technical PVC antioxidant and one of its components (the test substance). Contact allergy to the test item was very strong in 1 patient, and was the main cause of her hand dermatitis, whereas the other patient also had other contact allergies explaining her symptoms. Three patients reacted to their PVC gloves, but the specific allergen was not identified. Six PVC glove samples contained the test item at concentrations of 0.004–0.099%. The test item transforms into the phosphate during storage.


Conclusions. The test substance represents a new allergen in PVC gloves. It was detected in several PVC gloves in fairly high concentrations.