Registration Dossier
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EC number: 262-774-8 | CAS number: 61417-49-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 81-5 (Acute Dermal Irritation)
- Deviations:
- no
- Principles of method if other than guideline:
- 0.5 ml under gauze dressing to the clipped intact skin of adult albino rabbits for a period of 4 hr with observations for erythema and edma at 4, 24, 48 and 72 hr. Score of 5 or more is considered a primary irritant.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tris(isooctadecanoato-O)(propan-2-olato)titanium
- EC Number:
- 262-774-8
- EC Name:
- Tris(isooctadecanoato-O)(propan-2-olato)titanium
- Cas Number:
- 61417-49-0
- Molecular formula:
- Not applicable
- IUPAC Name:
- tris(isooctadecanoato-O)(propan-2-olato)titanium
Constituent 1
- Specific details on test material used for the study:
- Ken-React KR TTS
Lot R-1082S
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 hr.
- Observation period:
- 4, 24, 48 and 72 hr
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0.3
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Remarks on result:
- no indication of irritation
- Other effects:
- Non observed
Any other information on results incl. tables
E
| Erythema & Eschar | ||||||
| Animal # | 1 | 2 | 3 | 4 | 5 | 6 |
| 4 hr | 1 | 1 | 1 | 1 | 1 | 1 |
| 24 hr | 1 | 1 | 1 | 0 | 0 | 0 |
| 48 hr | 0 | 0 | 0 | 0 | 0 | 0 |
| 72 hr | 0 | 0 | 0 | 0 | 0 | 0 |
Edema score
0 for animals during the test.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The target substance is not irritating to skin with irritation score of 0.3.
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