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Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 2011-01-31 to 2011-02-18
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP lab, following OECD guidelines
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Deviations:
yes
Remarks:
The temperature was within a variation greater than 1°C for preliminary tests. Time-weighted mean was used for the calculation of exposure concentration and the limit of quantification was used for calculation of the concentration.
GLP compliance:
yes (incl. QA statement)
Analytical monitoring:
yes
Vehicle:
yes
Test organisms (species):
Daphnia magna
Test type:
semi-static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
48 h
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
> 16.37 mg/L
Nominal / measured:
meas. (TWA)
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 16.2 mg/L
Nominal / measured:
meas. (TWA)
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
24 h
Dose descriptor:
NOEC
Effect conc.:
16.4 mg/L
Nominal / measured:
meas. (TWA)
Conc. based on:
test mat.
Basis for effect:
mobility
Key result
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
16.2 mg/L
Nominal / measured:
meas. (TWA)
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
24 h
Dose descriptor:
EC100
Effect conc.:
> 16.4 mg/L
Nominal / measured:
meas. (TWA)
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
48 h
Dose descriptor:
EC100
Effect conc.:
> 16.2 mg/L
Nominal / measured:
meas. (TWA)
Conc. based on:
test mat.
Basis for effect:
mobility
Validity criteria fulfilled:
yes
Conclusions:
No immobilization was observed in the limit semi-static test. Therefore exact values of EC50 could not be calculated and the values of EC were given in the form of a range. The NOEC and EC100 values were identified by direct observation. Time weighted mean of determined concentrations were used for all evaluations and results.
Executive summary:

Young daphnids are exposed to the Propylal at a range of concentrations (100, 50, 10, 5 and 1 mg/l) for a period of 48 hours and compared with control values. The results are analyzed in order to calculate the EC50 at 48h. 20 animals, divided in groups of 10 each are used at each concentration and for the controls.

No immobilization was observed in the limit semi-static test. Therefore, the exact values of EC50 could not be calculated and the values of EC were given in the form of a range. The NOEC and EC100 values were identified by direct observation. Time weighted mean of determined concentrations were used for all evaluations and results.

Description of key information

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Dose descriptor:
EC50
Effect concentration:
> 16.2 mg/L

Additional information