N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxyadenosine

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017-09-22 to 2018-02-13

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

GLP compliance:

no

Type of method:

differential scanning calorimetry

Remarks:

Clarified by capillary tube in a metal block

Key result

Atm. press.:

ca. 1 013.3 hPa

Decomposition:

yes

Decomp. temp.:

>= 210 °C

A DSC measurement in an aluminium crucible with a hole showed endothermal effects after the melting in the temperature range of 245 - 280 °C and 280 - 345 °C. Due to the ambiguous course of the peaks and the incomplete mass loss an additional measurement with a capillary tube was conducted for clarification.

A measurement with the capillary method was performed to clarify the results of the DSC measurements. Since this measuremnet was performed only as a verifying screening a high heating rate of 10 K/min was chosen and therefore the absolute temperature values derived with the capillary method are not as accurate as the ones derived with the DSC method. The filling height of the test item in the sample tube was approx. 5 mm. Results of the measurement are summarized in Table 1.

Table 1: Results of the capillary method

No.	Set point / °C	Heating rate / K/min	End point / °C	Remarks
1	210	10	360	Approx. 210 °C: test item completely melted (yellowish melt) Approx. 229 °C: test item discoloured to brown Approx. 235 °C: formation of bubbles started Approx. 256 °C: bubbling increased, discoloured to nearly black Approx. 262 °C: test item boiled Approx. 275 °C: decreased bubbling Approx. 294 °C: weak formation of bubbles, discoloured to black Approx. 310 °C: increased bubbling

The capillary method measurement showed that the test item decomposed before boiling could occur. The decomposition products started to boil at approx. 236 °C. Under consideration of the result from the DSC measurements and the capillary method it was concluded that the test item had no boiling point at atmospheric pressure (1013.3 hPa). Above 210 °C decomposition started.

Conclusions:

The test item had no boiling point at atmospheric pressure (1013.3 hPa). Above 210 °C, decomposition of the test item started, indicated by a colour change from yellow to brown and then to black.

Executive summary:

The boiling point / boiling range of the test item was investigated by DSC measurement according to OECD 103 and confirmed by capillary method. The study showed that the test item starts to decompose at a temperature of approx. 210 °C and thus no boiling point could be determined before the decomposition. The test item has no boiling point under atmospheric conditions.

Description of key information

The boiling point / boiling range of the test item was investigated by DSC measurement according to OECD 103 and confirmed by capillary method. The study showed that the test item starts to decompose at a temperature of approx. 210 °C and thus no boiling point could be determined before the decomposition. The test item has no boiling point under atmospheric conditions.