Registration Dossier
Registration Dossier
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EC number: 246-181-1 | CAS number: 24345-02-6
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 442B (Skin Sensitization: Local Lymph Node Assay: BrdU-ELISA)
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA): BrdU-ELISA
Test material
- Reference substance name:
- Zinc bis[p-toluenesulphinate]
- EC Number:
- 246-181-1
- EC Name:
- Zinc bis[p-toluenesulphinate]
- Cas Number:
- 24345-02-6
- Molecular formula:
- C14H14O4S2Zn
- IUPAC Name:
- zinc bis(4-methylbenzenesulfinate)
- Test material form:
- solid: particulate/powder
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- Balb/c
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 0%, 5%, 10%, 25%, 50%
- No. of animals per dose:
- 5
- Positive control substance(s):
- not specified
Results and discussion
In vivo (LLNA)
Results
- Key result
- Parameter:
- SI
- Value:
- < 1.6
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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