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Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07 March 2016 to 20 July 2016
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
Lanolin, hydroxylated
EC Number:
270-315-8
EC Name:
Lanolin, hydroxylated
Cas Number:
68424-66-8
IUPAC Name:
Lanolin, hydroxylated
Test material form:
solid

Results and discussion

Water solubility
Key result
Water solubility:
0.016 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
100 mg/L
Incubation duration:
22 h
Temp.:
20 °C
pH:
5.9
Details on results:
Preliminary Test: The preliminary estimate of water solubility at 20.0 ± 0.5 °C was determined to be less than 2.86 x 10-2 g/L. The solution had a pH of 5.5.
Main Test: Overall concentration: less than 1.64E-02 g/L at 20.0 ± 0.5 °C

Any other information on results incl. tables

The concentration (g/L) of four test item components in the sample solutions at 20.0 ± 0.5 °C are shown in the following table:

Sample Number

Time Shaken at ~ 30 °C (hours)

Time Equilibrated at 20 °C (hours)

Concentration (g/L)

Solution pH

1

24

24

1.64E-02

5.9

2

48

24

1.40E-02

5.9

3

72

24

1.34E-02

5.9

Applicant's summary and conclusion

Conclusions:
The water solubility of the test item has been determined to be less than 1.64E-02 g/L at 20.0 ± 0.5 °C based on selected components. It was considered that the water solubility of the test item as a whole would be less than 1E-03 g/L.
Executive summary:

The water solubility of the test substance was less than 1.64E-02 g/L of solution at 20.0 ± 0.5 °C, using the flask method, designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995. It was considered that the water solubility of the test item as a whole would be less than 1E-03 g/L.