Registration Dossier
Registration Dossier
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EC number: 249-385-9 | CAS number: 29043-70-7
Endpoint summary
Administrative data
Description of key information
Skin irritation: not irritating in rabbits when test substance was
applied to the intact skin for 24 hours (Pharmatox, 1983a). The study
was conducted according to an appropriate OECD guideline.
Eye irritation: not irritating in rabbits when test substance was
applied undiluted to the eye (Pharmatox, 1983b). The study was conducted
according to an appropriate OECD guideline.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Dimethylbis(octadecyloxy)silane has been tested for acute skin irritation in an occlusive study conducted according to a protocol equivalent or similar to OECD TG 404 (Pharmatox, 1983a). The test substance was applied to the shaved and abraded skin of eight rabbits for twenty-four hours. No signs of skin irritation were observed. It is concluded that the test substance is not irritating to the skin.
Dimethylbis(octadecyloxy)silane has been tested for acute eye irritation in a study conducted according to a protocol equivalent or similar to OECD TG 405 (Pharmatox, 1983b). Conjunctival redness and discharge was observed in all animals one hour after test substance application but were resolved by 4 hours after application. It is concluded that the test substance is not irritating to eyes.
Justification for classification or non-classification
Based on the available data, dimethylbis(octadecyloxy)silane is not classified for skin or eye irritation according to Regulation (EC) No 1272/2008.
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