Registration Dossier
Registration Dossier
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EC number: 231-561-1 | CAS number: 7632-51-1
Endpoint summary
Administrative data
Description of key information
VCl4 is not a stable vanadium chloride. Its decomposition is driven by heat, dissolved Cl2 concentration, humidity or light, following the first equation:
VCl4 + H2O => VOCl2 + 4 HCL
The dissolution reaction in water (body humidity...) is exothermic, instantaneous (half-life of VCl4 < 1 hour – VCl4 can be considered as a hydrolytically unstable substance), gives white fumes of HCl and the pH of the solution is < 2.
Due this physico-chemical property (HCl generation) and the weight of evidence (industrial practice), VCl4 is considered as corrosive and test for acute toxicity are not performed for animal welfare considerations.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
With the physico-chemical property (HCl generation) and the weight of evidence (industrial practice), VCl4 is considered as corrosive and test for acute toxicity are not performed for animal welfare
considerations. For this reason, no classification for acute toxicity could be set.
Some oral LD50 are collected but due the date of data (1969) and the absence of details, this LD50 is not selected for classification. And, it is possible the cause of death is the effect of the corrosive property on the digestive tracts.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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