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EC number: 269-102-2 | CAS number: 68187-50-8 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77498.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The target substance showed minor dissolution of Fe in artificial gastric fluid after 2 h and 24 h incubation (94.2 ± 6.7 µg/L and 639 ± 166 µg/L respectively). No dissolved iron was detected in artificial sweat solution. Dissolution of Co was observed in artificial sweat after 2 h (31.3 ± 1.25 µg/L) and after 24 h (66.1 ± 6.66 µg/L). In artificial gastric fluid, Co was detected after 2 h (94.4 ± 4.18 µg/L) and after 24 h (362 ± 89.6 µg/L). In total, dissolution of Fe and Co is very low. Therefore, the pigment shows minor bioavailability in biological media.
Key value for chemical safety assessment
Additional information
A study was conducted with the objective to investigate the dissolution of the test item in the artificial physiological media GST (Artificial gastric fluid, pH = 1.5) and ASW (Artificial sweat solution, pH = 6.5). The test media were selected to simulate relevant human-chemical interactions, i.e. a substance entering the human body by ingestion or by inhalation. For the experimental setup the test item was weighed into flasks, adjusted to volume with the respective artificial physiological medium (loading of approx. 100 mg/L) and agitated. Samples were taken after 2 h and 24 h. The total dissolved iron and cobalt concentrations of sampled solutions were determined after filtration by ICP-OES.The test followed the experimental conditions of the OECD 29 guidance: 24 h agitation at 100 rpm inside an incubated laboratory shaker. The temperature in the thermostatically controlled incubation cabinet was adjusted to 37.5°C to obtain a temperature of 37 ± 2°C in the media to simulate the temperature of the human body.
The test item showed minor dissolution of Fe in artificial gastric fluid after 2 h and 24 h incubation (94.2 ± 6.7 µg/L and 639 ± 166 µg/L respectively). No dissolved iron was detected in artificial sweat solution. Dissolution of Co was observed in artificial sweat after 2 h (31.3 ± 1.25 µg/L) and after 24 h (66.1 ± 6.66 µg/L). In artificial gastric fluid, Co was detected after 2 h (94.4 ± 4.18 µg/L) and after 24 h (362 ± 89.6 µg/L) (Fraunhofer IME, 2017).
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