Registration Dossier
Registration Dossier
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EC number: 218-528-7 | CAS number: 2173-56-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 1964
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- probably according to OECD 401
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 964
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- old study, no GLP
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Pentyl valerate
- EC Number:
- 218-528-7
- EC Name:
- Pentyl valerate
- Cas Number:
- 2173-56-0
- Molecular formula:
- C10H20O2
- IUPAC Name:
- pentyl valerate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Amyl valerate (pentyl-pentanoate)
Test animals
- Species:
- rat
- Strain:
- Osborne-Mendel
- Remarks:
- guinea-pigs also tested
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- fasted for 18hrs prior to test, free access to water, food replaced after animals received their dose
Administration / exposure
- Route of administration:
- other: intubation
- Vehicle:
- unchanged (no vehicle)
- No. of animals per sex per dose:
- 10 young, adult rats (male and female), guinea pigs (male and female)
- Control animals:
- not specified
- Details on study design:
- all animals under close observation for 2 weeks for toxic signs and time of death,
where no acute toxic signs occured, the animals were observed for only 1 week. - Statistics:
- LD50s were computed by the method of Lichfield & Wilcoxon (1949)
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 35.42 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: guinea pigs: LD50 > 17.260 mg/kg bw
- Mortality:
- Death time: rats: 4hrs-5 days, no effects in 2 weeks observed
Death time: guinea pigs: 2-6 days, wet fur - Clinical signs:
- Rats: no effects observed
Guinea pigs: wet fur
Applicant's summary and conclusion
- Interpretation of results:
- other: old study, but valid
- Conclusions:
- The LD50s for amyl valeriate (pentyl pentanoate) are: for rats: <35.420 mg/kg bw, for guinea pigs: <17.260 mg/kg bw
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