Registration Dossier
Registration Dossier
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EC number: 283-815-6 | CAS number: 84731-55-5
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No acute toxicity data are available for lithium isooctadecanoate. The acute toxicity of lithium 12-hydroxystearate to Daphnia showed no effects at a water accommodated fraction loading rate of 100 mg/L. The 48 hour EL50 is determined to be > 100 mg/L WAF for lithium 12-hydroxystearate and this value has been read across to lithium isooctadecanoate.
Key value for chemical safety assessment
Additional information
No data are available for lithium isooctadecanoate and, therefore, data are read across from lithium 12-hydroxystearate- see IUCLID section 13 for read across justification. Lithium isooctadecanoate and lithium 12 -hydroxystearate are both lithium salts of C18 monocarboxylic acids, with lithium isooctadecanoate having a methyl branch on the carbon chain and lithium 12 -hydroxystearate having a hydroxyl group on the carbon chain.
The acute toxicity to Daphnia were determined in a GLP-compliant, limit test (Harlan 2013), following OECD guideline 202. As no effects were observed in the preliminary range finding test, the definitive toxicity to Daphnia test was conducted as a limit test at 100 mg/L, alongside a blank control. Twenty Daphnia, divided into four replicates, were exposed to water accommodated fractions of lithium 12-hydroxystearate for 48 hours in standard ecotoxicity media adjusted to a hardness of approximately 150 mg/L CaCO3. Observations of immobilisation or abnormalities of behaviour or appearance of the Daphnia were made at 24 and 48 hours and the test solutions analysed for lithium content and total organic carbon at test initiation and termination.
Lithium 12 -hydroxystearate has a 48 hour EL50 of >100 mg/L WAF toDaphnia. As the substance is not acutely toxic to Daphnia, it can be justifiably expected that lithium isooctadecanoate will not be acutely toxic to Daphnia either.
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