Registration Dossier
Registration Dossier
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EC number: 277-155-8 | CAS number: 72968-81-1
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity, LD50: > 2000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute Oral Toxicity
The study was performed to assess the acute oral toxicity of the Similar substance 01 following a single oral administration in the Sprague-Dawley rat. The method followed the OECD Guideline 423 (adopted 22 March 1996), EU Commission Directive 96/54/EEC method B1. No deaths occurred and no signs of systemic toxicity were noted during the study. The faeces of the females were stained orange on day 1. Necropsy did not revealed abnormalities. LD50 was > 2000 mg/kg bw (males and females).
The Similar susbtance 02 was tested for oral acute toxicity according to the Real Decree 363/1995, that is the transposition of Directive 67/548/EEC in Spanish legislation. The LD50 value is > 2000 mg/kg.
Based on the read-across principle, the results can be considered for the assessment of the registered substance.
Justification for read-across is detailed in the report attached to the IUCLID section 13.
Justification for classification or non-classification
Acute oral toxicity
According to the CLP Regulation 1272/2008/EC, 3.1.2.1 section, substances can be allocated to one of four toxicity categories based on acute toxicity by the oral, dermal or inhalation route according to the numeric criteria shown in Table 3.1.1:
Oral (mg/kg body weight)
Category 1: LD50 ≤ 5
Category 2: 5 <LD50 ≤ 50
Category 3: 50 < LD50 ≤ 300
Category 4: 300 < LD50 ≤ 2 000
The oral LD50 values are > 2000 mg/kg/body weight.
The substance is not classified for oral toxicity because it doesn't meet the classification criteria of the CLP regulation n.1272/2008.
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