Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-464-6 | CAS number: 60-24-2
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Justification for classification or non-classification
In accordance with section 1 of REACH Annex XI, testing does not appear to be scientifically necessary since negative genotoxicity data and consideration of its simple chemical structure provide sufficient weight of evidence to conclude 2-mercaptoethanol is unlikely to show any significant carcinogenic activity.
2-Mercaptoethanol has a low potential for carcinogenicity and therefore do not warrant classification under DSD or GHS/CLP.
Additional information
There are no carcinogenicity studies available for 2-mercaptoethanol. However, a consideration of its simple chemical structure, which has no reactive groups and carries no alerts for likely genotoxic carcinogenic activity from established Structure Activity Relationship analysis (Ashby and Tennant, 1988), together with the conclusion that 2-mercaptoethanol is not genotoxic, provide a strong case for concluding that it will not show any significant carcinogenic activity. Taking this information into account, it is considered that there is no justification for conducting further animal carcinogenicity studies. The above reasoning leads to the conclusion that 2-mercaptoethanol can be considered to have low concern for human carcinogenicity.
The following information is taken into account for any hazard / risk assessment:
No specific carcinogenicity data are available on 2-mercaptoethanol, however, its simple chemical structure with no reactive groups and no structural alerts for likely genotoxic carcinogenic activity, together with the conclusion that 2-mercaptoethanol is not genotoxic, provide a strong case for concluding that it not will show any significant carcinogenic activity.
References:
Ashby J and Tennant RW (1988) Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the U. S. NCI/NTP. Mutat Res 204: 17-115.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
