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EC number: 238-523-3
CAS number: 14516-71-3
In a reverse gene mutation assay in bacteria, strains of Salmonella
typhimurium TA100, TA1535, TA98, TA1537 and Escherichia coli WP2 uvrA
were exposed to TBBC (>98%) in DMSO at concentrations of 0, 0.781, 1.56,
3.13, 6.25, 12.5, 25 and 50 μg/plate (TA100, TA1535 and TA1537), 0, 3.13
- 200 μg/plate (TA98) and 0, 313 - 5000 μg/plate (WP2) and 0, 12.5, 25,
50, 100, 200, 400 and 800 μg/plate (TA100, TA1535, TA98 and TA1537) and
0, 313 - 5000 μg/plate (WP2) in the absence and presence of mammalian
metabolic activation respectively (Phenobarbital and
5,6-benzoflavone-induced rat liver S9).
Toxicity was observed at 12.5 μg/plate (TA100 and TA1537), 25 μg/plate
(TA1535) and 100 μg/plate (TA98) without S9 mix, and 400 μg/plate
(TA100, TA1535 and TA1537) and 500 μg/plate (TA98) with S9 mix. No
toxicity was observed in WP2 either without S9 mix or with S9 mix. The
positive controls induced the appropriate responses in the corresponding
strains. There was no evidence of induced mutant colonies over
This study is classified as acceptable. This study satisfies the
requirement for Test Guideline OECD 471 for in vitro mutagenicity
(bacterial reverse gene mutation) data.
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