Poly(polyalkylammonium) poly(µ-alkoxy)-µ6-oxido-polyhedropoly(chloridometal)ate polyalkanol solvate

Hydrolysis

Description of key information

A preliminary hydrolysis test was conducted. At 23 °C, six different test media were studied. Based on the results, a hydrolysis half-life of approximately 4.5 seconds at 23 °C can be derived. Hydrolysis was found too rapid for performing a main study according to OECD TG 111.

Key value for chemical safety assessment

Half-life for hydrolysis:

0.075 min

at the temperature of:

23 °C

Additional information

A preliminary hydrolysis test was conducted in order to determine the need for a main hydrolysis test and suitable experimental conditions for this main test. At 23 °C, six different test media were studied: buffer solutions at pH 4, 7 and 9; pure HPLC water; and acetonitrile / HPLC water mixtures at v/v ratios of 30 : 70 and 10 : 90. Pure acetonitrile served as reference where no hydrolysis occurred.

 

After less than 1:30 minutes (sample preparation, including chromatographic separation), only for the first injections of the sample in acetonitrile : HPLC water (90 : 10, v/v) a test item signal could be detected. The intensity of this signals corresponds to approx. 2.7% of the reference signal in pure acetonitrile, decreased dramatically for the second injection and no signal could be observed for the third injection (injection run time 2 minutes). Reference samples in acetonitrile indicate no fade of the test item signal. Therefore, the hydrolytic half-life of the test item was reported to be significantly below 1 minute at 23 °C. The same can be assumed for the environmental typical temperature range. Due to this fast transformation, no hydrolysis testing on basis of the OECD 111 guideline could be performed.

 

Based on the results for acetonitrile : HPLC water (90 : 10, v/v), a hydrolysis half-life of approximately 4.5 seconds at 23 °C can be derived.