Registration Dossier
Registration Dossier
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EC number: 228-544-6 | CAS number: 6291-84-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from NTRL
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Initial submission: Letter from Eastman Kodak Co to USEPA Regarding Basictoxicity of 3-methylaminopropylamine with Attachments and Cover Letter dated 9/4/92.
- Author:
- NTRL
- Year:
- 1 992
- Bibliographic source:
- OTS0555335, NTRL, dated 9/4/92
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute dermal toxicity study of 3-Methylaminopropylamine in Guinea pigs.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 3-aminopropylmethylamine
- EC Number:
- 228-544-6
- EC Name:
- 3-aminopropylmethylamine
- Cas Number:
- 6291-84-5
- Molecular formula:
- C4H12N2
- IUPAC Name:
- (3-aminopropyl)(methyl)amine
- Details on test material:
- SMILES:CNCCCN
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 3-Methylaminopropylamine
- Molecular formula (if other than submission substance): C4H12N2
- Molecular weight (if other than submission substance): 88.1528 g/mole
- Substance type: Organic
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Clipped backs of abdomen
- % coverage:
- Type of wrap if used: occlusive wrap were used
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data
- Time after start of exposure: No data
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 84.4 to 844 mg/kg
- Concentration (if solution): No data
- Constant volume or concentration used: No data
- For solids, paste formed: No data
VEHICLE
- Amount(s) applied (volume or weight with unit): No data
- Concentration (if solution): No data
- Lot/batch no. (if required): No data
- Purity: No data - Duration of exposure:
- 24 hours
- Doses:
- 84.4 to 844 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 24 hours
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: No data
- Other examinations performed: Mortality, skin reactions and gross pathology were observed. - Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 844 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No 50 % mortality observed
- Mortality:
- Two animals were died after 24 hours
- Gross pathology:
- Necroses and hemorrhage were observed in treated Guinea pigs.
- Other findings:
- Skin irritation:
Severe erythema was observed in treated Guinea pigs.
Skin sensitization:
No skin sensitization was observed in treated Guinea pigs.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- LD50 was considered to be >844 mg/kg when Guinea pigs were exposed with 3-aminopropylmethylamine on Clipped backs of abdomen by occlusive wrapping for 24 hours.
- Executive summary:
In acute dermal toxicity study,Guinea pigswere exposed with 3-aminopropylmethylamine in the concentration of84.4 to 844 mg/kgonClipped backs of abdomen by occlusive wrappingfor 24 hours.Two animals were died after 24 hours. Necroses and hemorrhage were observed in treated Guinea pigs. Severe erythema was observed in treated Guinea pigs. No skin sensitization was observed in treated Guinea pigs.Therefore,LD50 was considered to be>844 mg/kgwhen Guinea pigs were exposed with3-aminopropylmethylamineonClipped backs of abdomen by occlusive wrappingfor 24 hours.
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