Registration Dossier
Registration Dossier
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EC number: 421-830-3 | CAS number: 49805-30-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EEC, B1
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- -
- EC Number:
- 421-830-3
- EC Name:
- -
- Cas Number:
- 49805-30-3
- Molecular formula:
- C6H7NO
- IUPAC Name:
- 2-azabicyclo[2.2.1]hept-5-en-3-one
Constituent 1
Test animals
- Species:
- other: Rat (Sprague-Dawley)
Administration / exposure
- Vehicle:
- other: Distilled water
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 671 mg/kg bw
- 95% CL:
- >= 547 - <= 925
- Remarks on result:
- other: Slope of the mortality curve: 7.4
- Mortality:
- Male: 320 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 500 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 800 mg/kg bw; Number of animals: 5; Number of deaths: 3
Female: 320 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 500 mg/kg bw; Number of animals: 5; Number of deaths: 2
Female: 800 mg/kg bw; Number of animals: 5; Number of deaths: 4 - Clinical signs:
- other: Signs of toxicity related to dose levels: Pilo-erection was observed in all rats within five minutes of dosing and throughout the remainder of Day 1. This persisted and was accompanied on Day 1 and/or later intervals by: abnormal body carriage, abnormal g
- Gross pathology:
- Effects on organs:
No treatment related macroscopic findings were observed for
rats which died during the study or which were killed on Day
15.
Applicant's summary and conclusion
- Interpretation of results:
- other: harmful
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