Registration Dossier
Registration Dossier
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EC number: 812-378-1 | CAS number: 210420-85-2
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 18 November 2016 to 23 March 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Version / remarks:
- 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
- Version / remarks:
- 1996
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- estimation method (solubility ratio)
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Reference substance 001
- Cas Number:
- 210420-85-2
- Reference substance name:
- N-methyldidecylamine
- EC Number:
- 230-990-1
- EC Name:
- N-methyldidecylamine
- Cas Number:
- 7396-58-9
- Molecular formula:
- C21H45N
- IUPAC Name:
- N-decyl-N-methyldecan-1-amine
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- Dihydrogen oxide
- Reference substance name:
- Unknown impurities
- Molecular formula:
- Not available
- IUPAC Name:
- Unknown impurities
- Test material form:
- solid
- Details on test material:
- - Appearance: Slightly yellow gel
- Storage conditions: At room temperature; container flushed with nitrogen
Constituent 1
Constituent 2
Constituent 3
impurity 1
- Specific details on test material used for the study:
- the substance is surface active
Results and discussion
Partition coefficientopen allclose all
- Key result
- Type:
- Pow
- Partition coefficient:
- >= 4 100
- Temp.:
- 20 °C
- pH:
- ca. 8
- Type:
- Pow
- Partition coefficient:
- >= 4 200
- Temp.:
- 20 °C
- pH:
- ca. 8
- Remarks on result:
- other: corrected for the water content in the substance
- Key result
- Type:
- log Pow
- Partition coefficient:
- >= 3.6
- Temp.:
- 20 °C
- pH:
- ca. 8
Applicant's summary and conclusion
- Conclusions:
- The Pow of the substance at 20°C was estimated to be = 4.1E03 (log Pow = 3.6).
- Executive summary:
Because the substance is surface active both the HPLC method and the shake-flask method are not applicable. The log Pow of the substance was therefore estimated from the ratio 'n-octanol solubility and critical micelle concentration'. The Pow of the substance at 20°C was estimated to be = 4.1E03 (log Pow = 3.6) in a GLP study according to EC A.8, OECD 107 and OPPTS 830.7550.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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