2'-hydroxyacetophenone

Endpoint summary

Additional information

Short-term toxicity to fish:

A GLP test according to EPA OTS 797.1400 (Fish Acute Toxicity Test) has been conducted under static conditions with the marine water fish Cyprinodon variegatus (Hoechst Celanese Corp., 1996; J9602007d). After 96 hours of exposure a LC50 of 88.4 mg/L was determined, based on nominal concentrations. This data were used as key value for chemical safety assessment.

In addition, the toxic effect of 2'-hydroxyacetophenone (CAS 118-93-4) was studied in a GLP test according to EPA OTS 797.1400 (Fish Acute Toxicity Test) performed under static conditions with the freshwater fish Lepomis macrochirus as test species (Hoechst Celanese Corp., 1996; J9602007b). After 96 hours of exposure a LC50 of 115 mg/L was determined, based on nominal concentrations.

The substance is concluded to be acutely harmful to fish.

 

Short-term toxicity to aquatic invertebrates:

Acute toxic effects of 2-hydroxyacetophenone (CAS 118-93-4) to aquatic invertebrates were studied in a GLP study following the TSCA Environmental Effects Testing Guideline 797.1300 using Daphnia magna as test species (Hoechst Celanese Corporation, 1996, J9602007a). Based on nominal test concentrations the 48-h EC50 was determined to be 56.5 mg/L.

The result is supported by an acute toxicity test with the seawater mysid, Mysidopsis bahia (Hoechst Celanese Corporation, 1996, J9602007c), which resulted in an 96 h EC50 of 44.2 mg/L, indicating toxic effects of the substance to freshwater and marine invertebrates to be of an equivalent magnitude. According to REACh guidance Chapter R.10 the data for Daphnia is preferred in terms of chemical safety assessment.

2-hydroxyacetophenone is concluded to be acutely harmful to aquatic invertebrates.

 

Toxicity to aquatic algae and cyanobacteria:

In a GLP, 120-hour static test with the green alga Selenastrum capricornutum, according to FIFRA Guideline Number 123 -2 (EPA), the algae toxicity of 2 -hydroxyacetophenone was investigated. Statistical re-evaluation of the endpoint cell number revealed an IC50 (120h) of >100 mg/L; the IC10 (120h) was estimated to be 36.6 mg/L, both related to nominal test concentrations.

In conclusion, the substance is with a high probability acutely not harmful to aquatic algae and cyanobacteria.

Toxicity to microorganisms:

Information on the toxicity of 2-hydroxyacetophenone towards the microorganism Tetrahymena pyriformis has been reported in three publications (Devillers, 2004, Jalali-Heravi, 2008 and Jiang et al. 2011) without giving details on the methods. The reported IGC50 is the same in all three publications, even if different publications are mentioned as sources (no source, Cronin and Schultz, 2001, and Cronin et al., 2002, respectively). The IGC50 of 113 mg/L indicates that the inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations.