Registration Dossier
Registration Dossier
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EC number: 230-597-5 | CAS number: 7212-44-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data available as short summary from a secondary source beeing cited in a peer-reviewed publication
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Acute oral and dermal toxicity studies
- Author:
- Russell TJ
- Year:
- 1 973
- Bibliographic source:
- Report to RIFM (Location 2033, Sub-Reference 03/06); cited in: Opdyke DLJ (1975): Monographs on Fragrance Raw Materials. Food Cosmet Toxicol 13: 887
Materials and methods
- Principles of method if other than guideline:
- No data given.
- GLP compliance:
- not specified
- Test type:
- other: no data given
Test material
- Reference substance name:
- 3,7,11-trimethyldodeca-1,6,10-trien-3-ol,mixed isomers
- EC Number:
- 230-597-5
- EC Name:
- 3,7,11-trimethyldodeca-1,6,10-trien-3-ol,mixed isomers
- Cas Number:
- 7212-44-4
- Molecular formula:
- C15H26O
- IUPAC Name:
- 3,7,11-trimethyldodeca-1,6,10-trien-3-ol
- Details on test material:
- - Name of test material (as cited in study report): Nerolidol
- Analytical purity and isomere specification: no data given
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- No data given.
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- Observation period lasted 14 days. The animals were observed for moratlity and clinical signs of toxicity.
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No deaths occured.
- Clinical signs:
- No effects were seen.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
