Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 903-139-3 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- A read-across justification is provided in the IUCLID chapter "assessment reports"
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- European Interlaboratory Evaluation of an in Vitro Ocular Irritation Model (Skin2TM Model ZKll00) Using 18 Chemicals and Formulated Products
- Author:
- Joller PW et al.
- Year:
- 1 994
- Bibliographic source:
- Alternatives to Animal Testing. New Ways in the Biomedical Sciences, Trends and Progress. Reinhardt, C.A. (ed.). VCH, Weinheim.
Materials and methods
- Principles of method if other than guideline:
- Testing of chemicals in an in vitro Ocular Irritation Model (Skin2TM Model ZK1100) in an interlaboratory study
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Pentan-1-ol
- EC Number:
- 200-752-1
- EC Name:
- Pentan-1-ol
- Cas Number:
- 71-41-0
- Molecular formula:
- C5H12O
- IUPAC Name:
- pentan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): 1-Pentanol
Constituent 1
Test animals / tissue source
- Species:
- other: Skin2TM Model ZK 110 (Advanced Tissue Sciences Inc., La Jolla, CA)
- Strain:
- not specified
Test system
- Vehicle:
- other: medium
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2 ml
- Concentration (if solution): 0.1, 0.3, 1.0, 3.0, 10.0% - Duration of treatment / exposure:
- one application
- Observation period (in vivo):
- not applicable
- Number of animals or in vitro replicates:
- not applicable
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
SCORING SYSTEM:
acc. to in the Journal officièl de la République Française (24.10.84)
Results and discussion
Any other information on results incl. tables
Data of LDH and PGE2 were not given, although stated that PGE2 values correspond to values of irritancy.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
