Registration Dossier
Registration Dossier
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EC number: 201-557-4 | CAS number: 84-74-2
Biotransformation and kinetics
Administrative data
- Endpoint:
- biotransformation and kinetics
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
Test material
- Reference substance name:
- Dibutyl phthalate
- EC Number:
- 201-557-4
- EC Name:
- Dibutyl phthalate
- Cas Number:
- 84-74-2
- Molecular formula:
- C16H22O4
- IUPAC Name:
- dibutyl phthalate
Constituent 1
Results and discussion
- Transformation products:
- yes
Identity of transformation products
- No.:
- #1
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- 100-54-3
- Identifier:
- CAS number
- Identity:
- 100-54-3
Any other information on results incl. tables
Di-n-butylphthalate was rapidly converted by rainbow traut liver microsomes to unextractable compound present in the aqueous phase (Table 16). Approximately 40% of the radiolabeled compound was converted within 15 min, and 60% within 1 hr. Irreversible protein binding occurred throughout the 2 hr incubation with 14C labeled di-n-butylphthalate. Approximately 9% of the radiolabeled compound was bound to the trout liver microsomes during a 2 hr incubation with 7% of the total bound in the first 15 min of incubation.
Radiolabeled di-n-butylphthalate was converted more slowly by Daphnia PMS during a 1 hr incubation than by trout liver microsomes. Only about 10% of the radiolabeled compound was converted (Table 16) to water soluble hexane unextractable compounds. Less than 1% of the di-n-butylphthalate was irreversibly bound to protein.
Applicant's summary and conclusion
- Conclusions:
- The study showed that protein binding of di-n-butylphthalate occurred in rainbow traut liver microsomes and to a more limited extent in Daphnia PMS.
- Executive summary:
Radiolabeled (14C) di-n-butylphthalate was incubated with a protein substrate and NADPH generating system to determine metabolism and irreversible protein binding of di-n-butylphthalate in rainbow traut liver microsomes and daphnia PMS.
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