Registration Dossier
Registration Dossier
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EC number: 203-397-0 | CAS number: 106-43-4
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: exposure against chlorotoluene (isomer not specified)
Data source
Reference
- Reference Type:
- publication
- Title:
- Research in industrial health in the chemical industry
- Author:
- Goldblatt MW
- Year:
- 1 995
- Bibliographic source:
- Br J Ind Med 12, 1-20
Materials and methods
- Type of study / information:
- Type of experience: Human
- Principles of method if other than guideline:
- Toxic concentrations of various gases, dusts, fumes and metals in the working atmosphere were presented in tabular form
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-chlorotoluene
- EC Number:
- 203-397-0
- EC Name:
- 4-chlorotoluene
- Cas Number:
- 106-43-4
- Molecular formula:
- C7H7Cl
- IUPAC Name:
- 4-chlorotoluene
- Details on test material:
- no data
Constituent 1
Method
- Details on study design:
- no data
- Exposure assessment:
- not specified
Results and discussion
- Results:
- experience with occupational exposure to an unspecified mixture of o- and p-chlorotoluene or to the isomere:
400 ppm (= 2.106 mg/m³): Mono-chlorotoluene causes severe toxic effects in persons exposed by inhalation for 60 min.;
200 ppm (= 1.053 mg/m³): Mono-chlorotoluene may lead to symptoms of illness in persons, if the exposure continues for more than a short time; 75 ppm (= 0.395 mg/m³): concentrations in general atmosphere of plant or greater may lead to unsatisfactory conditions (no further data)
Any other information on results incl. tables
see Executive summary
Applicant's summary and conclusion
- Executive summary:
- experience with occupational exposure to an unspecified mixture of o- and
p-chlorotoluene or to the isomere:
400 ppm (= 2.106 mg/m³):
Mono-chlorotoluene causes severe toxic effects in persons exposed by inhalation for 60 min.;
200 ppm (= 1.053 mg/m³):
Mono-chlorotoluene may lead to symptoms of illness in persons, if the exposure continues for more than a short time;
75 ppm (= 0.395 mg/m³):
concentrations in general atmosphere of plant or greater may lead to unsatisfactory conditions (no further data)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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