Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 256-062-6
CAS number: 43048-08-4
The acute oral toxicity of the test item was evaluated in rats according
to the OECD guideline 423 and the GLP principles.
The test item was prepared in corn oil and was administered by oral
route (gavage), under a volume of 10 mL/kg to groups of 3 fasted female
Sprague-Dawley rats. Clinical signs, mortality and body weight gain were
checked for a period of up to 14 days following the single
administration of the test item.
As no information on the toxic potential of the test item was available,
for animal welfare reasons, the starting dose-level of 300 mg/kg was
chosen. No mortality and clinical signs were observed at this dose. So
two other groups were treated with 2000 mg/kg/day. No mortality occured
but hypoactivity and piloerection were observed in 3/6 animals on day 1
A slighlty reduced body weight gain was seen in 2/3 given 300 mg/kg
during the second week of the study. At the 2000 mg/kg dose-level, a
reduced body weight gain was recorded in 1/6 females during the first
week of the study and in 2/6 females during the second week of the
study. The overall body weight gain of the other animals was not
considered to be affected by treatment with the test item.
At necropsy, no apparent abnormalities were observed in any animal.
Under the experimental conditions of this study, the oral LD50 of the
test item was higher than 2000 mg/kg/day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again