Registration Dossier
Registration Dossier
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EC number: 202-039-0 | CAS number: 91-08-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: as per mentioned below
- Principles of method if other than guideline:
- To evaluate the toxicity of 2,6Toluene diisocyanate in Photobacterium phosphoreum by MicrotoxTM test
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No data available - Analytical monitoring:
- not specified
- Details on sampling:
- No data available
- Vehicle:
- not specified
- Details on test solutions:
- No data available
- Test organisms (species):
- Photobacterium phosphoreum
- Details on inoculum:
- No data available
- Test type:
- static
- Water media type:
- saltwater
- Total exposure duration:
- 30 min
- Post exposure observation period:
- No data available
- Hardness:
- No data available
- Test temperature:
- 15C
- pH:
- 5< pH <9
- Dissolved oxygen:
- No data available
- Salinity:
- No data available
- Nominal and measured concentrations:
- No data available
- Details on test conditions:
- No data available
- Reference substance (positive control):
- not specified
- Duration:
- 30 min
- Dose descriptor:
- EC50
- Effect conc.:
- 42 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Increase in the light emission.
- Details on results:
- No data available
- Results with reference substance (positive control):
- No data available
- Reported statistics and error estimates:
- No data available
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The EC50 was found to be 42 mg/L for 2,6Toluene diisocyanate in Photobacterium phosphoreum by MicrotoxTM test.
- Executive summary:
Toxicity to microorganism was determined in2,6Toluene diisocyanate inPhotobacterium phosphoreum by MicrotoxTM test. The test was conducted for 5 ,15 and 30 minutes .The EC50 for 30 min was found to be 42 mg/L.
Reference
Description of key information
Toxicity to microorganism was determined in2,6Toluene diisocyanate inPhotobacterium phosphoreum by MicrotoxTM test. The test was conducted for 5 ,15 and 30 minutes .The EC50 for 30 min was found to be 42 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 42 mg/L
Additional information
Toxicity to microorganism was determined in2,6Toluene diisocyanate inPhotobacterium phosphoreum by MicrotoxTM test. The test was conducted for 5 ,15 and 30 minutes .The EC50 for 30 min was found to be 42 mg/L.
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