Zinc bis(dinonylnaphthalenesulphonate)

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1978

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: limited report, non GLP, no data on weight gain and no macroscopic evaluation. The information allows the derivation of an LD50. The information in the report is limited to the information in the summary.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

other: FHSLA, CFR, Title 21, para. 191.1.

Test guideline 2

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

no iiformation on bodyweight gain, clinical signs and macroscopic investigations

Principles of method if other than guideline:

no report on bodyweight (end of study), no details on clinical findings and no macroscopy

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Zinc bis(dinonylnaphthalenesulphonate)

EC Number:

248-778-2

EC Name:

Zinc bis(dinonylnaphthalenesulphonate)

Cas Number:

28016-00-4

Molecular formula:

Zn[C28H43O3S]2

IUPAC Name:

Zinc bis(di C8-C10, branched, C9 rich, alkylnaphthalenesulphonate))

Test material form:

liquid: viscous

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: not indicated
- Weight at study initiation: males: 200-218 g; females 203-217 g
- Fasting period before study: 18 hours
- Housing: individually
- Diet/water: no data

ENVIRONMENTAL CONDITIONS: no information available

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

MAXIMUM DOSE VOLUME APPLIED: 5 mL/kg

Doses:

2000 mg/kg bw (based on concentration in material)

No. of animals per sex per dose:

5 males + 5 females

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: clinical observations and mortality check daily: weighing at the start of the study
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs

Statistics:

NA

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

act. ingr.

Effect levels 2

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 mL/kg bw

Based on:

test mat.

Mortality:

none

Clinical signs:

other: animals appeared healthy and normal

Gross pathology:

not performed

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The LD50 of the test substance is > 2000 mg/kg bw

Executive summary:

In a limit test 5 rats/sex received 2000 mg/kg bw of the test substance by gavage. No mortality or clinical signs were observed during the 14 day observation period. The LD50 is > 2000 mg/kg bw.