α,2,4-trichlorotoluene

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

no

GLP compliance:

no

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

α,2,4-trichlorotoluene

EC Number:

202-381-0

EC Name:

α,2,4-trichlorotoluene

Cas Number:

94-99-5

Molecular formula:

C7H5Cl3

IUPAC Name:

2,4-dichloro-1-(chloromethyl)benzene

Test material form:

liquid

Test animals

Species:

rat

Strain:

Wistar

Sex:

female

Details on test animals or test system and environmental conditions:

SPF-rats (Wistar TNO W 74, breeding: Winkelmann, Borchen)
Age: ca. 14 weeks
Average starting BW: 184 g

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

0.1; 0.5; 1.0; 1.1; 1.2; 1.3; 1.4 ml/kg

No. of animals per sex per dose:

10

Details on study design:

The rats were kept in a makrolon cage type III. 5 animals per cage. The animals were fed with Altromin R 1324 (Altromin GmbH, lage) and tap water ad libitum.

Statistics:

Probit-Analysis

Results and discussion

Effect levels

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

1.003 mL/kg bw

Based on:

test mat.

95% CL:

>= 0.775 - <= 1.156

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

The LD50 for acute oral toxicity is 1.00 ml/kg BW or based on a density of 1.408 g/ml 1.410 mg/kg BW