Diphenyl sulphide

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Justification for type of information:

Data is from peer-reviewed journal

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Range-Finding Toxicity Data: List VI

Author:

HENRY F. SMYTH, JR., Ph.D., CHARLES P. CARPENTER, Ph.D., CARROL S. WEIL, M.A., URBAN0 C. POZZANI, M.S., and JEAN. A. STRIEGEL, B.S.

Year:

1962

Bibliographic source:

American Industrial Hygiene Association Journal, V.23:2, pages 95-107 1962

Reference 2

Reference Type:

other: authoritative database

Title:

Skin irritation study for Diphenyl sulphide/ Phenyl Sulfide (CAS No. 139-66-2)

Author:

GSBL

Year:

2018

Bibliographic source:

GSBL, Joint Substance Data Pool of the German Federal Government and the German Federal States, 2018

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

The primary skin irritation study was conducted for Diphenyl sulphide/ Phenyl Sulfide (CAS No. 139-66-2) on albino rabbits.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Diphenyl sulphide

EC Number:

205-371-4

EC Name:

Diphenyl sulphide

Cas Number:

139-66-2

Molecular formula:

C12H10S

IUPAC Name:

(phenylsulfanyl)benzene

Test material form:

liquid

Details on test material:

Name of test material (as cited in study report): Diphenyl sulphide
Molecular formula:C12H10S
Molecular weight:186.277 g/mol
Smiles : c1(Sc2ccccc2)ccccc1
InChI : 1S/C12H10S/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h1-10H
Substance Type: Organic
Physical State: Liquid

Specific details on test material used for the study:

- Name of test material (as cited in study report): Phenyl sulfide
- Molecular formula: C12H10S
- Molecular weight: 186.277 g/mole
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:

rabbit

Strain:

other: Albino New Zealand

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: No data available
- Age at study initiation: No data available
- Weight at study initiation: 2.5 to 3.5 kg
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): No data available
- Water (e.g. ad libitum): No data available
- Acclimation period: No data available
- Sex: Male

ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available

IN-LIFE DATES: From: To: No data available

Test system

Type of coverage:

occlusive

Preparation of test site:

clipped

Vehicle:

other: Undiluted sample or of solutions in water, propylene glycol, or acetone

Controls:

not specified

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit):0.01 mL

Duration of treatment / exposure:

24-hours

Observation period:

24-hours

Number of animals:

5

Details on study design:

TEST SITE
- Area of exposure: Rabbit belly
- % coverage: No data available
- Type of wrap if used: No data available

REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data available
- Time after start of exposure: Exposed for 24-hour

SCORING SYSTEM:
A 10-grade ordinal series and is based upon the severest reaction that develops on the clipped skin of each of five albino rabbits within 24 hours of the uncovered application of 0.01 ml of undiluted sample or of solutions in water, propylene glycol, or acetone. Grade 1 indicates no irritation and Grade 2 the least visible capillary injection from the undiluted chemical. Grade 6 indicates necrosis when undiluted and Grade 10 indicates necrosis from a 0.01% solution.

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

24 h

Score:

5

Max. score:

10

Reversibility:

no data

Remarks on result:

positive indication of irritation

Applicant's summary and conclusion

Interpretation of results:

Category 2 (irritant) based on GHS criteria

Conclusions:

The primary skin irritation study was conducted for Diphenyl sulphide/ Phenyl Sulfide (CAS No. 139-66-2) on albino rabbits. A score of 5 was recorded. Hence, it was concluded that Diphenyl sulphide/ Phenyl Sulfide (CAS No. 139-66-2) was irritating to the skin of albino rabbits under the experimental conditions tested and classified as “Category- 2: Irritant” as per CLP criteria.

Executive summary:

The primary skin irritation study was conducted for Diphenyl sulphide/ Phenyl Sulfide (CAS No. 139-66-2) on albino rabbits. The test item phenyl sulfide was applied on the clipped skin of each of five albino rabbits within 24 hours of the uncovered application of 0.01 ml of undiluted sample or of solutions in water, propylene glycol, or acetone. A score of 5 was recorded. Hence, it was concluded that Diphenyl sulphide/ Phenyl Sulfide (CAS No. 139-66-2) was irritating to the skin of albino rabbits under the experimental conditions tested and classified as “Category- 2: Irritant” as per CLP criteria.