Registration Dossier
Registration Dossier
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EC number: 930-964-6 | CAS number: -
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No data on test method. No GLP.
Data source
Reference
- Reference Type:
- publication
- Title:
- Materials for experimentally substantiation of maximally permissible concentration of monochloroacetic acid in the air of production area
- Author:
- Maksimov GG, Dubinina ON
- Year:
- 1 974
- Bibliographic source:
- Gig. Tr. Prof. Zabol. (1974), 9, 32-37
Materials and methods
- Principles of method if other than guideline:
- The sensitisation effect of monochloractic acid was studied on rabbits for 30 days.
No more data provided on the method. - GLP compliance:
- no
- Type of study:
- open epicutaneous test
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): МХУК
- Physical state: colorless hygroscopic crystals
In vivo test system
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- no data
- Concentration / amount:
- Induction: 0.1, 1.5, 10 and 50% solution
Challenge: 5 % solution
Challengeopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- no data
- Concentration / amount:
- Induction: 0.1, 1.5, 10 and 50% solution
Challenge: 5 % solution
- No. of animals per dose:
- No data
- Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 1
- Concentrations: 1 drop of 0.1, 1.5, 10 and 50% solution
- Area of exposure: 6 cm2
B. CHALLENGE EXPOSURE
- No. of exposures: 30
- Exposure period: 30 days, daliy
- Evaluation (hr after challenge): 10 drops of 5 % solution
- Area of exposure: 6 cm2 - Positive control substance(s):
- not specified
Results and discussion
Any other information on results incl. tables
Applicant's summary and conclusion
- Interpretation of results:
- other: due to the limited reporting of this study is not considered reliable for the evaluation of the sensitizing potential of the substance.
- Conclusions:
- No animals were sensitized.
- Executive summary:
The sensitisation effect of monochloractic acid was studied experimentally on rabbits for 30 days.
No animals were sensitized.
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