Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-970-5 | CAS number: 7782-91-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Three recently conducted guideline-conform, highly reliable state-of-the-art genotoxicity tests produced unequivocally negative results, and thus provide strong evidence for an absence of concern for genotoxic effects of molybdenum substances, which is supported by reliable supplementary data.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
The following recently conducted guideline-conform, highly reliable state-of-the-art genotoxicity tests with a soluble molybdenum substance (sodium molybdate) are available:
- an AMES bacterial reverse mutation assay (Beevers, 2009),
- an in vitro micronucleus assay in human lymphocytes (Taylor, 2009), and
- an in vitro gene mutation assay (tk) in mouse lymphoma cells (Lloyd, 2009).
All three tests produced unequivocally negative results, and thus provide strong evidence for an absence of concern for genotoxic effects of molybdenum substances. Since the substance tested represents a highly soluble molybdate, and molybdic acid has been shown to transform rapidly to molybdate anions upon dissolution in aqueous media, these results can be read across to molybdic acid without restriction. In conclusion, no classification of molybdic acid for genotoxicity is required.
Apart from these high quality, reliable GLP test results, additional supporting studies exist, the outcome of which can be summarised as follows:
(i) unequivocally negative results were obtained in guideline-conform, valid bacterial reverse mutation assay for high purity (moderately soluble) molybdenum trioxide (study by Jones, 2004).
(ii) negative results were obtained in an in-vitro mammalian cell micronucleus test conducted also with molybdenum trioxide (study by Fox, 2005).
Justification for classification or non-classification
Based on the review of key experimental studies as well as supportive information on genetic toxicity, no classification of molybdic acid is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
