2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data is from BASF study reports

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other:

Principles of method if other than guideline:

Acute oral toxicity test of Lumogen LT light yellow in rat by single exposure.

GLP compliance:

not specified

Test type:

other: no data

Test material

Test material information

Constituent 1

Reference substance name:

2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone

EC Number:

219-210-0

EC Name:

2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone

Cas Number:

2387-03-3

Molecular formula:

C22H16N2O2

IUPAC Name:

1,1'-(hydrazine-1,2-diylidenedimethylylidene)di(2-naphthol)

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

- Name of test material (as cited in study report):Lumogen LT light yellow (chemical name: 2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone)- Molecular formula (if other than submission substance):C22H16N202- Molecular weight (if other than submission substance):340,385g/mol- Smiles notation (if other than submission substance):Oc1c(c2c(cccc2)cc1)\C=N\N=C\c1c2c(cccc2)ccc1O- InChl (if other than submission substance):1S/C22H16N2O2/c25-21-11-9-15-5-1-3-7-17(15)19(21)13-23-24-14-20-18-8-4-2-6-16(18)10-12-22(20)26/h1-14,25-26H/b23-13+,24-14+- Substance type:Organic- Physical state:Solid

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

No details available

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

CMC (carboxymethyl cellulose)

Details on oral exposure:

VEHICLE- Concentration in vehicle: 15% suspention- Amount of vehicle (if gavage): 0.5% aqueous solution

Doses:

4600 mg/kg

No. of animals per sex per dose:

No details available

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days- Frequency of observations and weighing: Clinical sign observed - Necropsy of survivors performed:NO- Other examinations performed: No details available

Statistics:

No data

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 4 600 mg/kg bw

Based on:

test mat.

Remarks on result:

other: no mortality was observed

Mortality:

no mortality observed in treated rats.

Clinical signs:

other: Yellow colored feces were observed in treated rats.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated informationCriteria used for interpretation of results: EU

Conclusions:

LD50 was considered to > 4600 mg/kg bw when rats were treated with Lumogen LT light yellow orally.

Executive summary:

In a acute oral toxicity study, rats treated with Lumogen LT light yellow at 4600 mg/kg bw in 0.5% aqueous carboxymethylcellulose preparation by single exposure and animals were observed for 14 days. No effect on survival of treated rats was observed. Yellow colored feces were observed in treated rats. Therefore, LD50 was considered to > 4600 mg/kg bw when rats were treated with Lumogen LT light yellow orally.