Registration Dossier
Registration Dossier
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EC number: 227-458-6 | CAS number: 5850-86-2
Endpoint summary
Administrative data
Description of key information
not eye irritant for rabbits
not skin irritant for rabbits
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Some studies are available both for skin and eye irritation based on the patch-test method described in Hazardous Substances Regulation, US Federal Hazardous Labelling Act. Sect. 191-11 (February 1965)
The results show:
- no eye irritation for observation at 1, 24, 48 and 72 h.
- no skin irritation for observation at 1, 24, 48 and 72 h.
Acid Orange 8 doesn't show any irritating effects based on the available tests for similar substance 01 and as a consequence it could be stated that is not corrosive or irritant.
Justification for selection of skin irritation / corrosion endpoint:
The study was performed on a tested substance with a higher content of active ingredient.
Justification for selection of eye irritation endpoint:
The study was the most complete and assessed the effect on cornea, iris and conjunctiva.
Justification for classification or non-classification
No classification for skin irritation/corrosion is warranted under CLP Regulation (EC n. 1272/2008)
No classification for eye irritation/corrosion is warranted under CLP Regulation (EC n. 1272/2008)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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