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EC number: 237-529-3
CAS number: 13826-66-9
Table 1: Mortality
Dose [mg/kg bw]
No. of animals
Table 2: Maximum incidence of systemic clinical signs
Table 3: Nature and duration of local clinical signs
Table 4: Individual body weight changes
Body weight at study day [g]:
Table 5: Gross pathology
In an acute dermal toxicity study (Limit Test), young adult Wistar rats
(5 males and 5 females) were dermally exposed to a single dose of 2000
mg/kg bw of the test substance (as suspension in corn oil Ph. Eur.). The
clipped application site (dorsal and dorso-lateral parts of the trunk,
comprising at least 10 % of the total body surface) was covered by
semi-occlusive dressing during the 24-hour exposure period. The animals
were observed for 14 days.
- No mortality occurred.
- Neither signs of systemic toxicity nor local skin effects were
- The body weight of all male animals and of two out of five female
animals increased within the normal range throughout the study period.
Two other female animals showed slight loss of body weight during the
first week, while another animal showed stagnation of body weight within
this week. All three females gained weight in a normal range during the
second week. Due to the fact that stagnation or slight loss of body
weight is commonly known for females after dermal applications, this
stagnation is considered to be unspecific.
- No macroscopic pathologic abnormalities were noted in any animal
examined at the end of the study (5 males and 5 females).
Accordingly, the acute dermal median lethal dose (LD50) was determined
to be > 2000 mg/kg bw for male and female rats.
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