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EC number: 500-214-9 | CAS number: 68440-06-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the water solubility limit.
Key value for chemical safety assessment
Additional information
Since no studies investigating the short-term toxicity of Fatty acids, C18-unsatd., dimers, hydrogenated, 2-ethylhexyl esters (CAS 68440-06-2) to aquatic invertebrates are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance Fatty acids, C18-unsatd., dimers, 2-ethylhexyl esters (CAS 68334-05-4) was conducted. The source substance is representative to evaluate the short-term toxicity of the target substance to aquatic invertebrates.The target substance Fatty acids, C18-unsatd., dimers, hydrogenated, 2-ethylhexyl esters (CAS 68440-06-2) is characterized by two dimerised fatty acid moieties (C18) esterified with the alcohol component 2-ethylhexanol. The source substance Fatty acids, C18-unsatd., dimers, 2-ethylhexyl esters (CAS 68334-05-4) is characterized as a dimerised ester of two C18:1 fatty acids esterified with 2-ethylhexanol.This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment.
The study with the read-across substance Fatty acids, C18-unsatd., dimers, 2-ethylhexyl esters (CAS 68334-05-4) was conducted according to OECD 202 (GLP) for 48 h in a static system using Daphnia magna (Swarbrick and Smyth, 2005). As the test substance has a low water solubility (16 ± 7 µg/L at 20 °C, pH 6.3) water accommodated fractions (WAFs) with a loading rate of 100 mg/L were used during this test. No effect up to the limit of the water solubility of the tested substances was observed (EL50 > 100 mg/L; NOELR ≥ 100 mg/L).
Based on the available results from a structurally related source substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded Fatty acids, C18-unsatd., dimers, hydrogenated, 2-ethylhexyl esters will not exhibit short-term effects to aquatic invertebrates up to the limit of water solubility.
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