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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to microorganisms, other
Remarks:
QSAR
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2015
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
The target lipid model (TLM) is a framework that relates toxicity to the physicochemical properties of a nonpolar organic constituent. It is a well documented and peer reviewed model that is widely used across the petrochemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.
Qualifier:
no guideline required
Principles of method if other than guideline:
The endpoint calculated is the LL50, EL50, and NOELR -
The narcosis target lipid model was developed to predict the toxicity of chemicals to aquatic organisms that act via narcosis. It is based on the hypothesis that target lipid is the site of toxic action within the organism, that octanol is the appropriate surrogate, and that target lipid has the same physical–chemical properties in all organisms.
The approach describes:
• The theory and how to predict the acute toxicity to these organisms;
• Development of an Acute to Chronic ratio [ACR] for only hydrocarbons and for 29 data points.
Specific details on test material used for the study:
N/A
Details on sampling:
N/A
Details on test solutions:
N/A
Test organisms (species):
activated sludge
Details on inoculum:
N/A
Post exposure observation period:
N/A
Hardness:
N/A
Test temperature:
N/A
pH:
N/A
Dissolved oxygen:
N/A
Salinity:
N/A
Conductivity:
N/A
Nominal and measured concentrations:
N/A
Details on test conditions:
N/A
Key result
Duration:
72 h
Dose descriptor:
other: EL50
Effect conc.:
1 760.893 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Details on results:
N/A
Reported statistics and error estimates:
N/A

N/A

Conclusions:
The estimated 72-hr EL50 value for activated sludge is 1760.893 mg/L.
Executive summary:

The aquatic toxicity of this substance was estimated using the Target Lipid Model based on methodologies described by Mcgrath et al. (2004). The estimated 72-hr EL50 value for activated sludge is 1760.893 mg/L.

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Description of key information

The aquatic toxicity of this substance was estimated using the Target Lipid Model based on methodologies described by Mcgrath et al. (2004).The estimated 72-hr EL50 value for activated sludge is 1760.893 mg/L.

Key value for chemical safety assessment

EC50 for microorganisms:
1 760.893 mg/L

Additional information